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Research endeavors in Yonsei DNA Profiling Group cover a wide range of forensic and human genetics including population studies of DNA polymorphisms, DNA typing methodologies and strategies, DNA databases and data quality control, and evolutionary demographics.

Rapidly increasing amounts of data from a variety of sources requires the ability to evaluate and integrate this information in order to make meaningful research. As we are interested in the application of mitochondrial DNA to kinship analysis and evolutionary genetics, a forensic mitochondrial DNA database, mtDNAmanager (http://mtmanager.yonsei.ac.kr) was recently developed by our group. It is a web-based bioinformatics resource aimed at supporting mitochondrial DNA data quality control and generating reliable frequency estimates from various population groups. This application provides an easily accessible web interface for researchers to determine if a mitochondrial DNA sequence is reliable for further analysis, and thus should be very useful for population, medical, and forensic studies that employ mitochondrial DNA analysis. In addition, we are now working together with the MAKRI (Ministry of Naional Defense Agency for Killed In Action Recovery and Identification) in order to identify the missing casualties of the Korean War (1950-1953). To facilitate obtaining DNA profiles from highly degraded samples such as old skeletal remains, we have also developed a modified mini-primer set for the mitochondrial DNA control region sequence analysis and several mini-STR systems for autosomal- and Y-chromosomal STR analyses.

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Selected Recent Publications:

11. Kim NY, Lee HY, Park MJ, Yang WI, Shin KJ. A genetic investigation of Korean mummies from the Joseon Dynasty. Mol Biol Rep. 2010; In press.
10. Lee HY, Park MJ, Kim NY, Sim JE, Yang WI, Shin KJ. Simple and highly effective DNA extraction methods from old skeletal remains using silica columns. Forensic Sci Int Genet. 2010; In press.
9. Sim JE, Lee HY, Yang WI, Shin KJ. Population genetic study of four closely-linked X-STR trios in Koreans. Mol Biol Rep. 2010;37(1):333-337.
8. Lim EJ, Lee HY, Sim JE, Yang WI, Shin KJ. Genetic polymorphism and haplotype analysis of 4 tightly linked X-STR duos in Koreans. Croat Med J. 2009;50(3):305-312.
7. Lee HY, Song I, Ha E, Cho SB, Yang WI, Shin KJ. mtDNAmanager: a Web-based tool for the management and quality analysis of mitochondrial DNA control region sequences. BMC Bioinformatics. 2008;9(1):483.
6. Lee HY, Yoo JE, Park MJ, Kim CY, Shin KJ. Genetic characterization and assessment of authenticity of ancient Korean skeletal remains. Hum Biol. 2008;80(3):239-250.
5. Lee HY, Kim NY, Park MJ, Yang WI, Shin KJ. A modified mini-primer set for analyzing mitochondrial DNA control region sequences from highly degraded forensic samples. BioTechniques. 2008;44(4):555-558.
4. Park MJ, Shin KJ, Kim NY, Yang WI, Cho SH, Lee HY. Characterization of deletions in the DYS385 flanking region and null alleles associated with AZFc microdeletions in Koreans. J Forensic Sci. 2008;53(2):331-334.
3. Chung U, Shin KJ, Park MJ, Kim NY, Yang WI, Cho SH, Lee HY. Population data of nine miniSTR loci in Koreans. Forensic Sci Int. 2007;168(2-3):e51-e53.
2. Lee HY, Park MJ, Chung U, Lee HY, Yang WI, Cho SH, Shin KJ. Haplotypes and mutation analysis of 22 Y-chromosomal STRs in Korean father-son pairs. Int J Legal Med. 2007;121(2):128-135.
1. Park MJ, Lee HY, Chung U, Kang SC, Shin KJ. Y-STR analysis of degraded DNA using reduced-size amplicons. Int J Legal Med. 2007;121(2):152-157.

 

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