- mtDNAmanager (http://mtmanager.yonsei.ac.kr)
||mtDNAmanager is a web-based forensic mitochondrial bioinformatics resource aimed at supporting data quality control and generating reliable frequency estimates, using a new approach based on haplogroup estimation and data comparison with the contents of a given database. mtDNAmanager consists of previously reported world-wide forensic mtDNA sequences, and a set of bioinformatics tools, able to automatically characterize newly submitted data by estimating its haplogroup according to the haplogroup-specific control region mutation motif. Upon registration, the data can be imported and stored with batch mode. A query system enables us to search sequences which show a match or include the queried nucleotide polymorphisms having options to select analysis regions (HV1, HV2, HV3 and control region), ignore heteroplasmic insertions at poly C-stretches and permit mismatch. A match system not only permits retrieval of matched sequences for a sample of a data group but also enables cross match of all samples between two selected data groups. In both systems, mtDNAmanager also calculates frequency estimates for random matches in a selected group or the database.
- Y-STR database (Korean Y-STR haplotype and Y haplogroup)
||To construct a Korean Y-chromosomal STR database for 22 Y-STRs (DYS19, DYS385, DYS388, DYS389I/II, DYS390, DYS391, DYS392, DYS393, DYS437, DYS438, DYS439, DYS446, DYS447, DYS448, DYS449, DYS456, DYS458, DYS464, DYS635, and GATA H4.1), 708 DNA samples from unrelated Korean males were analyzed. Six DYS448 null types (allele nomenclature: 0) were detected, and arrangement analysis of sequence tagged sites demonstrated that the deletion patterns at DYS448 were associated with arrangements of the azoospermia factor c gene. In haplotype analysis for the 22 Y-STRs, a total of 693 different haplotypes were observed with overall haplotype diversity of 0.9999, and of these, 680 haplotypes were unique. The combined haplotypes of DYS447, DYS458, DYS635, GATA H4.1, and SWGDAM Y-STR loci was comparable to haplotypes of 17 loci in the AmpFlSTR® Yfiler™ kit.